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Services Offered:

1) 2D Gel Electrophoresis

2) LC MS/MS  more
Other Services  more

Prof. Dr. Shamshad Zarina

Research Interests:

Protein Structure function relationship, Proteomics, Bioinformatics. Proteomic profiling studies on oral carcinoma in Pakistan. Role of glycation in development of cataract formation. Taxon specific crystallins, Antioxidant enzymes and their expression. Drug screening against DNA and RNA viruses. Drug induced apoptosis studies on liver cancer cell lines. Using bioinformatics tools to understand structure function relationship of proteins.

Selected Publications:

Malik, U.U., Zarina, S., Pennington, S.R. Oral squamous cell carcinoma: Key clinical questions, biomarker discovery, and the role of proteomics, Archives of Oral biol., 63:53-65
Zohaib, M., Ansari, S.H., Hashim, Z., Shamsi, T.S., Zarina, S. Serum Paraoxonase activity and Malondialdehyde serum levels remain unaffected in response to Hydroxyurea therapy in b-thalassemia patients. J. Clinic. Pharmacol., (accepted)
Baig, A., Zohaib, M., Ata-ur-Rehman, Zarina, S. Q192R Paraoxonase1 Polymorphism is a risk factor for Cataract in Pakistani population, Pakistan Journal of Pharmaceutical Sciences (accepted)
Naseeb, N. Axelsson, J., Jagerbrink, T., Shafqat, J., Zarina S., Jornvall, H Complementary LC-MS/MS Proteomic Analysis of Uremic Plasma Proteins. JCPSP, 25 (8): 606-609
Ilyas, A., Hashim, Z. Zarina, S. Effects of 5-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective. Molecular and Cellular Biochemistry 405:53-61
Atta, A., Ilyas, A., Hashim , Z., Ahmed, A., Zarina, S. Lactate Dehydrogenase Like Crystallin: A Potentially Protective Shield for Indian Spiny-Tailed Lizard (Uromastyx hardwickii) Lens Against Environmental Stress? Protein Journal 33:128-134
Ilyas, A., Hashim, Z. Naeem, N., Haneef, K. and Zarina, S. The Effect of Alendronate on Proteome of Hepatocellular Carcinoma Cell Lines. International Journal of proteomics 2014:9 pages
Malik, U.U, Siddiqui, IA., Hashim, Z. and Zarina, S. Measurement of Serum Paraoxonase Activity and MDA levels in patients suffering with Oral Squamous Cell Carcinoma. Clin Chem acta 430:38-42
Anwar, S., Iqbal, MP., Zarina, S. and Bhutta, ZA. Evolutionary journey of Gc protein (vitamin D binding protein) across vertebrates. Intrinsically Disordered Proteins (accepted)
Dawood, S., Zarina, S. and Bano, S. Docking studies of antidepressants against single Crystal structure of tryptophan 2, 3-dioxygenase Using molegro virtual docker software. Pak. J. Pharmaceutical Chem. (accepted)
Siddiqui, S., Khan, I., Zarina, S. and Ali, S. Use of the SYBR Green Dye for Measuring Helicase Activity. Enzyme Microb Technol.52(3)196-8
Hashim, Z. and Zarina, S. Osmotic stress induced oxidative damage: Possible mechanism of cataract formation in diabetes. Journal of Diabetes and Its Complications 26(4) 275-9.
Azam, SA and Zarina, S. Distribution of biological databases over low-bandwidth networks. Bioinformation 8(5): 239-242.
Saleem, A., Azam, SA and Zarina, S. Docking and Molecular Dynamics Simulation Studies on Glycation Induced conformational Changes of Human Paraoxonase 1. Eur. Biophysics J. 41(2):241-8.
Hashim, Z and Zarina, S., Advanced Glycation End Products in diabetic and non-diabetic human subjects suffering from cataract. AGE 33(3) 377-84.
Ul-Haq Z, Khan W, Zarina S, Sattar R, Moin ST. "Template-based structure prediction and molecular dynamics simulation study of two mammalian Aspartyl-tRNA synthetases." J. Mol. Graph. Model. 28; 401-412.
Hashim Z, Ilyas A, Saleem A, Salim A, Zarina S. Expression and activity of paraoxonase 1 in human cataractous lens tissue. Free Radic Biol Med. 46; (8), 1089-95.
Naseeb U, Shafqat J, Jagerbrink T, Zarina S, Alvestrand A, Jornvall H, Axelsson J. Proteome patterns in uremic plasma. Blood Purif. 26; (6), 561-8.
Hashim Z. and Zarina S. "Assessment of Paraoxonase activity and lipid peroxidation levels in diabetic and senile subjects suffering from cataract". Clin. Biochem. 40; 705-709.
Hashim Z. and Zarina S. "Antioxidant Markers in human senile and diabetic cataractous lenses". J.Coll. Physicians Surg.Pak. 16; 637-640.
Zarina, S. and Zaidi, Z.H. Homology modeling of Rho-crystallin from Bullfrog (Rana catesbeiana) lens. J. Molecular Graphics and Modelling 22; (4), 285-291.
Thampi, P., Zarina, S. and Abraham, E.C.a-crystallin Chaperone Function in Diabetic Rat and Human Lenses. Molecular and Cellular Biochemistry 229; (1), 113-118.
Zarina, S., Zhao, H-R., Abraham, E.C. Advanced Glycation end products in human senile and diabetic cataract lenses.Molecular and Cellular Biochemistry, 210; 29-34.
Zarina, S., Slingsby, C., Jaenicke, J., Zaidi, Z.H., Driessen, H. and Srinivasan, N. "Three dimensional model and quaternary structure of the human eye lens protein γS-crystallin based on β and γ-crystallin X-ray coordinates and ultracentrifugation".Protein Science 3; 1840; 1846.
Zarina, S., Abbasi, A. and Zaidi, Z.H. "Cataractous lens and its environment". Pure and Applied Chemistry, 66;(1), 111-115.
Zarina, S., Abbasi, A. and Zaidi, Z.H. "Primary structure of βs-crystallin from human lens". Biochem. J. 287; (2), 375-381.Molecular and Cellular Biochemistry, 210; 29-34.