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Services Offered:

1) 2D Gel Electrophoresis

2) LC MS/MS  more
3)
Other Services  more



 
 
 
 
 
Dr. Zehra Manzoor


Research Interests:

Comparative proteomics, biomarker identification and drug induced modifications in Breast, liver and oral cancer tissues and cell lines. This includes cell culture, protein extraction, protein characterization, 2DE and mass spectrometry. Role of glycation and glycoxidation in cataract formation. Function of antioxidant enzymes and their expression in lens opacity. Identification of taxon specific lens crystallins.

Publications:

2015
Zohaib, M., Ansari, S.H., Hashim, Z., Shamsi, T.S., Zarina, S. Serum Paraoxonase activity and Malondialdehyde serum levels remain unaffected in response to Hydroxyurea therapy in b-thalassemia patients. J. Clinic. Pharmacol., (accepted)
2015
Ilyas, A., Hashim, Z. Zarina, S. Effects of 5-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective. Molecular and Cellular Biochemistry 405:53-61
2014
Atta, A, Ilyas, A, Hashim, Z, Ahmed A and Zarina, S. Lactate Dehydrogenase Like Crystallin: A Potentially Protective Shield for Indian Spiny-Tailed Lizard (Uromastyx hardwickii) Lens Against Environmental Stress? Protein J DOI 10.1007/s10930-014-9543-4
2014
Ilyas, A., Hashim, Z., Naeem, N., Haneef, K. and Zarina, S. The Effect of Alendronate on Proteome of Hepatocellular Carcinoma Cell Lines. International Journal of proteomics 2014:9 pages.
2014
Malik, U.U, Siddiqui, IA., Hashim, Z. and Zarina, S. Measurement of Serum Paraoxonase Activity and MDA levels in patients suffering with Oral Squamous Cell Carcinoma. Clin Chem acta 430: 38-42.
2012
Hashim, Z. and Zarina, S. Osmotic stress induced oxidative damage: Possible mechanism of cataract formation in diabetes. Journal of Diabetes and Its Complications 2012; 26: 275-279.
2011
Hashim, Z and Zarina, S., Advanced Glycation End Products in diabetic and non-diabetic human subjects suffering from cataract. AGE 33(3) 377-84.
2009
Hashim, Z., Ilyas A., Saleem A., Salim A., Zarina S. "Expression and activity of paraoxonase 1 in human cataractous lens tissue". Free Radic. Biol.Med. 46; 1089-1095.
2007
Hashim Z. and Zarina S. "Assessment of Paraoxonase activity and lipid peroxidation levels in diabetic and senile subjects suffering from cataract". Clin. Biochem. 40; 705-709.
2006
Hashim Z. and Zarina S. "Antioxidant Markers in human senile and diabetic cataractous lenses". J.Coll. Physicians Surg.Pak. 16; 637-640.